Due to pitfalls of dependancy, abuse, and misuse with opioids, even at advisable doses [see Warnings and Precautions (five.one)], reserve promethazine HCl and codeine phosphate oral Remedy to be used in adult sufferers for whom the many benefits of cough suppression are anticipated to outweigh the pitfalls, As well as in whom an ample assessment of the etiology in the cough is built.

Promethazine Hydrochloride and Codeine Phosphate Oral Option is actually a prescription medicine Utilized in Grown ups to temporarily treat cough and higher respiratory indicators which you can have with allergy symptoms or a standard cold.

Lifetime-threatening breathing problems (respiratory melancholy). Promethazine Hydrochloride and Codeine Phosphate Oral Solution can result in breathing complications (respiratory melancholy) which will come about Anytime during treatment method and can result in Loss of life. Your chance of breathing problems is biggest if you first start taking Promethazine Hydrochloride and Codeine Phosphate Oral Remedy, are taking other medicines that can cause breathing difficulties, have specific lung issues, are elderly or have sure other health conditions.

The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complicated, requiring very careful thing to consider of the results within the mother or father drug, codeine, plus the active metabolite, morphine.

are breastfeeding or intend to breastfeed. Codeine Phosphate passes into your breast milk and will hurt your child. You and your healthcare company should really explore irrespective of whether you ought to acquire Promethazine with Codeine Oral Option or breastfeed. You shouldn't do both.

Mainly because these reactions can be documented voluntarily from a population of unsure dimensions, It is far from normally possible to reliably estimate their frequency or create a causal romantic relationship to drug exposure.

Steer clear of using promethazine HCl and codeine phosphate oral Resolution in individuals who are taking a CYP2D6 inhibitor. If concomitant utilization of promethazine HCl and codeine phosphate oral Answer with inhibitors of CYP2D6 is critical, observe clients for signs and indicators that may reflect opioid toxicity and opioid withdrawal [see Drug Interactions (7.three)].

The codeine in promethazine HCl and codeine phosphate oral Alternative might trigger spasm from the sphincter of Oddi, leading to an increase in biliary tract tension.

5.2 Lifetime-Threatening get more info Respiratory Despair Serious, daily life-threatening, or deadly respiratory melancholy has become noted with using opioids, including codeine, among the Lively ingredients in promethazine HCl and codeine phosphate oral Alternative. Codeine generates dose-connected respiratory depression by directly acting on the Mind stem respiratory center that controls respiratory rhythm and will produce irregular and periodic breathing. Codeine is subject to variability in metabolism primarily based on CYP2D6 genotype, which can lead to an elevated exposure to the Lively metabolite morphine [see Warnings and Safety measures (5.

Put the mixture inside of a container like a sealed plastic bag and throw it away from the household trash. You may also stick to your state or local recommendations on how to safely toss away Promethazine Hydrochloride and Codeine Phosphate Oral Answer.

We foresee reposting the pictures as soon as we've been equipped detect and filter out illustrations or photos that do not match the data offered within the drug labels. NDC Codes

Labor or Delivery Opioids cross the placenta and could create respiratory melancholy and psycho-physiologic outcomes in neonates. An opioid antagonist, such as naloxone, needs to be available for reversal of opioid-induced respiratory melancholy from the neonate. Opioids, including promethazine HCl and codeine phosphate oral Remedy, can extend labor by actions which briefly decrease the power, length, and frequency of uterine contractions.

Avoid the usage of promethazine HCl and codeine phosphate oral Alternative in adolescents 12 to 18 a long time of age who produce other danger aspects that will improve their sensitivity on the respiratory depressant results of codeine Until the benefits outweigh the dangers.

In people with circulatory shock, promethazine HCl and codeine phosphate oral Remedy may possibly result in vasodilation which will further more cut down cardiac output and blood pressure level. Stay clear of the usage of promethazine HCl and codeine phosphate oral Alternative in clients with circulatory shock.